Selected Publications of CH Brenner
Brenner CH (2014)
Understanding Y haplotype matching probability
Forensic Sci. Int. Genet. 8 233–243
Analogizing to autosomal methods is a really poor way to start. No product rule is just one reason of many. The paper lists eight important ways in which the population genetic theory, the facts, and the behavior of rare haplotypes are very different.
Kijeong Kim; Charles H Brenner; Victor H Mair; Kwang-Ho Lee; Jae-Hyun Kim;
Eregzen Gelegdorj; Natsag Batbold; Yi-Chung Song; Hyeung-Won Yun; Eun-Jeong Chang;
Keun-Cheol Kim; Ae-Ja Park; Dong-Sub Sohn; Inja Lim; Dae-Jin Kim; Yoon-Hee Chung; Sung-Su
Kim; Won-Bok Lee; Kyung-Yong Kim (2010)
A Western Eurasian male is found in 2000-year-old Elite Xiongnu Cemetery in Northeast Mongolia
American Journal of Physical Anthropology 2010 Jul;142(3):429-40
(published on-line January 2010 DOI 10.1002/ajpa.21242)
Science News article January 29, 2010: Skeleton of Western man found in ancient Mongolian tomb
Brenner CH (2010)
problem of forensic mathematics
The evidential value of a rare haplotype
Forensic Sci. Int. Genet. 4 281–291
abstract and comments on this paper
Brenner CH (2007 letter) Counterexample to a conjecture of Krawczak For Sci International: Genetics, 2 2008 p75
Brenner CH (2006July15)
Forensic Genetics: Mathematics
Encyclopedia of Life Sciences
John Wiley & Sons, Ltd: Chichester http://www.els.net/ [doi: 10.1038/npg.els.0005451] Standard Article
draft version for download Basic concepts of using DNA for evidence including
Gill P, Brenner CH, Buckleton JS, et al. (2006July13)
DNA commission of the International Society of Forensic Genetics:
Recommendations on the interpretation of mixtures
For Sci International,160 (2-3), 90-101
Download from ISFG site
If a crime stain isn't matched in the offender database, there's still a good chance that its relative is there. The relative can likely be found by "kinship" searching if you know how to search. If the search results in a list of even dozens of potential relatives, sort them out with Y-haplotyping. This approach could significantly increase the effective reach of offender database. It could also raise some hackles and some eyebrows.
Brenner CH (Mar 2006)
mathematical problems in the DNA identification of
victims in the 2004 tsunami and similar mass fatalities
For Sci International,157, 172-180
Abstract and links
- Related victims missing, one found
- Related victims missing, several found
- Distinguishing race using DNA
Forensic STR markers are powerful for racial estimation
- Which races to calculate in disaster identifcation?
- Combining DNA and other identification information
Biescker LG, et al (2005Nov18) DNA Identifications After the 9/11 Trade Center Attack Science 310, 1122-1123
Brenner CH, Inman K (Jan 2004) Commentary on: Thompson WC, Taroni F, Aitken CGG, How the Probability of a False Positive Affects the Value of DNA Evidence J For Sci
Brenner CH (2004) Multiple mutations, covert mutations and false exclusions in paternity casework Progress in Forensic Genetics 10, 112-114. Eds. Doutremépuich, Morling, Elsevier Science B.V.
Buard J, Brenner CH, Jeffreys AJ (April 2002)
Evolutionary fate of an unstable human
minisatellite deduced from sperm mutation spectra of
Am J Hum Genet
Brenner CH (2001) Family secrets revealed, Progress in Forensic Genetics 9, Eds B Brinkmann et al.
Gill P, Brenner C, Brinkmann B, Budowle B, Carracedo A, Jobling MA, de Knijff P, Kayser M, Krawczak M, Mayr WR, Morling N, Olaisen B, Pascali V, Prinz M, Roewer L, Schneider PM, Sajantila A, Tyler-Smith C (2001) technical note: DNA Commission of the International Society of Forensic Genetics: recommendations on forensic analysis using Y-chromosome STRs Int J Leg Med 114:(6)305-309 abstract
Tamaki K, Brenner CH, Jeffreys AJ (2000) Distinguishing minisatellite mutation from non-paternity by MVR-PCR, Forensic Science International 113:55-62 (as the Proceedings of the 4th International Symposium on Advances in Legal Medicine (ISALM))
Brenner CH (1999) Kinship Analysis by DNA When There Are Many Possibilities, Progress in Forensic Genetics 8, Eds G Sensabaugh et al.
Yoshida K, Kasai K, Sato H, Brenner CH, Sensabaugh GF (1998) Genetic Variation at 6 STR Loci in the Japanese Population, Progress in Forensic Genetics 7, Eds. B Olaisen, B Brinkmann, PJ Lincoln, Elsevier Science B.V. 360-362
Brenner CH (1997)
Probable Race of a Stain Donor,
Proceedings from the Seventh Human Identification Symposium,
Promega Corp 48-52
Can you tell the race of a DNA sample? Yes.
Brenner CH, Fimmers R, Baur MP (1996) Likelihood Ratios for Mixed Stains When the Number of Donors Cannot be Agreed, Int J Legal Med 109(4):218-219
Brenner CH (1996) Hardy-Weinberg Equilibrium in RFLP Databases, Advances in Forensic Haemogenetics 6, Ed A Carracedo, B Brinkmann, W Bär, Springer Verlag 96-98
Brenner CH (1994) Clouding the Simpson DNA Issue, (Op-Ed) Los Angeles Times, September 4
Brenner CH (1994) Evaluation of the Product Rule, Advances in Forensic Haemogenetics 5, Ed W. Bär, A. Fiori and U. Rossi, Springer Verlag 453-455
Brenner CH, Morris JW (1990) Paternity Index Calculations in Single Locus Hypervariable DNA Probes: Validation and Other Studies Proceedings for The International Symposium on Human Identification 1989, Promega Corporation 21-53
has a lot of meat —
download in Word Perfect format
- We cracked the mystery of apparent excess homozygysity in RFLP systems, a big deal because many experts had drawn incorrect and consequential conclusions from misunderstanding the phenomenon,
- useful identities and approximations for typical paternity index and exclusion,
- validation methods, Hardy-Weinberg and linkage independence analysis years ahead of its time, behavior of gel migration.
Gjertson DW, Brenner CH, Baur MP, Carracedo A, Guidet F, Luque JA, Lessig R, Mayr WR, Pascali VL, Prinz M, Schneider PM, Morling N (2007) ISFG: Recommendations on Biostatistics in Paternity Testing, Review Article for Forensic Science International: Genetics 1(3)223-231
Abstract: The Paternity Commission of the International Society for Forensic Gentics has formultated recommendations on the use of biostatistics in the evaluation of results of genetic analyses in paternity cases and other situations with disputed genetic (family) relations.
Sawaguchi T, Brenner CH, Sawaguchi A (1998) Application of DNAVIEW & PATER to a kinship paternity case Rom J Leg Med 6(1)66-70
Morris JW, Garber RA, D'Autremont J, Brenner CH (1988)
The Avuncular Index and the Incest Index,
Advances in Forensic Haemogenetics 2, Springer-Verlag, 607-611
This is Jeff's paper. I get my name on it for inventing the term "Avuncular Index" which has stuck although as Ronnie Garner pointed out according to Latin it should refer to the maternal uncle.
Brenner CH (1985) Evidence, Probability, and Paternity, (letter) Am J Hum Genet 826-827
p(n|2, 3, 6, 9, 10 mod 12) ~ q(n|2, 3, 4, 6, 7, 8, 9, 10, 11, 12 mod 12), where
p(n|S) is the number of partitions of n into parts belonging to S,
q(n|T) is the number of partitions of n into distinct parts belonging to T,
and ~ here denotes asymptotic equality.
For example with n=10 and S, T the sets stated, e.g. S is positive numbers that are
2, 3, 6, 9, or 10 greater than a multiple of 12: