PATER

PATERNITY EVALUATION AND REPORT PROGRAM

This program is a self-contained product for preparation of formal paternity reports with many allied facilities. It works very naturally with DNA•VIEW for DNA types and also deals thoroughly with classical blood groups.

to mention just a few of PATER's capabilities.
Prices (including 1 year of maintenance, upgrade, support, and warranty) inquire
Inquiries to: email contact
Charles Brenner home page
Shown here is the "inclusion" format to be sent to the client or lawyer.
The headings, footings, and choice of columns are user-configurable.
Other customization is available on request including other languages -- Deutsch, Portugues
PATERNITY REPORT
Long Island Laboratories
(800)551-1111
Tested Man: Reverend Mr. Dimmesdale (C) 1000-00036
Mother:     Hester Prynne           (C) 1000-00034
Child:      Pearl                   1000-00035
SUMMARY OF FINDINGS:
    Reverend Mr. Dimmesdale is not excluded as the father of Pearl.
    Combined paternity index = 27000000
    Probability of paternity = 99.999996% (50% prior probability)

     T E S T         OBSERVED PHENOTYPES          CALCULATION OF PATERNITY INDEX 

                                     Tested     Paternity   Nonpaternity    Ratio
                 Mother    Child     Man        Assumed (X) Assumed (Y)     (X/Y)
PCR loci
    D8S1179      12 14     12 15     14 15      0.25        0.101           2.47
    D21S11       30 30     30.2      29 30.2    0.5         0.0154          32.5
    D7S820       8 12      12        12         0.5         0.0545          9.17
    CSF1PO       12 12     14        10 14      0.5         0.0112          44.7
    D3S1358      15 17     15        15 17      0.25        0.153           1.63
    TH01         8         8         8 9.3      0.5         0.208           2.4
    D13S317      12 11     12        11         1           0.246           4.06
    D16S539      9 11      9 11      9 11       0.5         0.254           1.97
    TPOX         8         8         8          1           0.362           2.76
    D18S51       14 17     16 17     12 16      0.25        0.0832          3
    D5S818       11 13     11 12     12 13      0.25        0.183           1.37
    FGA          25 22     25 22     24         0.5         0.217           2.31

cc: John J Fitzmorton Patricia M. Cavenaugh Office of the District Attorney 1422 N. Hampshire St. Walden, Ohio Walden, Ohio


Below is the laboratory-internal version, with some exclusions.
The headings, footings, and choice of columns are user-configurable.
Tested man: (C) Eltinge, JulianWho?   24-9876      Case 171
Mother:     (C) Herbert, Mathilda 24-1010      March 3, 1997 10:36
Child:          Bicious, Biddney  24-9988
SUMMARY: Exclusion Hp 6-PGD FILING CODES: F RIV rE fH mH - t13 (PATER ver 3.1.1) Excluding systems with an inconsistency -- Paternity Index = 572; Probability of paternity = 0.998 (at 50% prior); Probability of Exclusion (given mother and child) = 99.9925%
     T E S T         OBSERVED PHENOTYPES          CALCULATION OF PATERNITY INDEX  
                                     Tested     Paternity   Nonpaternity    Ratio    Random Man
                 Mother    Child     Man        Assumed (X) Assumed (Y)     (X/Y)    Eligible  

Red Cell Antigens
    ABO          A1        A2        A          0.0813      0.0556          1.464    1
    Rh           DCcE      DCcE      DCcEe      0.2481      0.0778          3.19     0.2891
    MNSs         N         MN        M          1           0.562           1.779    0.808
    Duffy        a+b-      a+b+      a+b+       0.479       0.557           0.861    0.824

Serum Proteins
    Gc           1f-2      1f-2      1s-1f      0.25        0.215           1.163    0.675
    Hp           2         2         1        Inconsistent  0.577                    0.821

Red Cell Enzymes
    AcP          AC        BC        AB         0.25        0.3057          0.818    0.849
    6-PGD        A         A         C        Inconsistent  0.982                    1
    ADA          2-1       2-1       2-1        0.5         0.5             1.001    1
    PGM          1-        1-        1          0.1905      0.144           1.323    0.942

HLA
    A locus      2,11      2,11      2,32       0.01395     0.00457         3.053    0.0666
    B locus      14,21     14,21     14,40

DNA Probes (bp)
    pS194/D7S104 5740      5740      5740       0.5         0.1766          2.831    0.322
        Pst I    6990      6990      6990

    TBQ7/D10S28  1230      1230      1780       0.25        0.034           7.35     0.0337
        Hae III  950       1450      1450


The HLA recombination rate is taken as 0.01. However, using 0 recombination in HLA X/Y=2.911 and P{C|M,M}=0.5. B21=(21,49,W50) B40=(40,W41,W47,W48,W60,W61)
cc:
       John J Fitzmorton                     Patricia M. Cavenaugh
       Office of the District Attorney       1422 N. Hampshire St.
       Walden, Ohio                          Walden, Ohio

Effect of prior probability on the likelihood of paternity:
  prior probability (%)         10     20     30     40     50     60     70     80     90
  likelihood of paternity (%)  98.5   99.3   99.6   99.7   99.8   99.9   99.93  99.96  99.98

                   Avuncular and Incest Indices
   Degree (0=alleged father or parthenogenesis, 1=uncle, etc.) of
   relation      0      1      2      3      4
Paternal         0     15.44   6.87   3.2    1.913
Maternal         0     39.3   51.5   25.39  11.16

On the basis of the genetic observations listed above (that are consistent with paternity) Julian Eltinge would be 572 times as likely to father Biddney Bicious as would a random man of similar ethnic background.




Sample Frequency and Detail Worksheet from PATER

Below are examples of some advanced features of PATER. With the Detail Worksheet the program shows the details of its serological calculation, which lets the user trace the computation process and be sure that it is correct and correctly understood.
ABO Frequency tables in use 1991/3/20 11:20
Caucasian Hispanic Black Asian
O 0.664 0.812 0.707 0.584
B 0.074 0.056 0.127 0.171
A2 0.066 0.021 0.041 0.006
A1 0.196 0.111 0.125 0.239


DETAIL calculation worksheet ****** ABO
ABO    Computation of X=P{C|M,tested man is father} = 0.05116
   Mother: A1   Child: A2   Tested man: A
                      Paternal genes
                        A2     A1     O      A2     A1
               Sperm=   O      O      A2     A2     A2
       Pat frequency= 0.0736 0.3888 0.0736 0.0019 0.0101
Maternal genotype     Likelihood of A2 phenotype:
       Ovum   M freq
A1     O      0.4362                 0.0321 0.0008 0.0044
A1     A2     0.0253   0.0019 0.0098 0.0019       0.0003
ABO        Computation of Y=P{C|M,random man} = 0.01754
   Mother: A1   Child: A2
                      Paternal genes
               Sperm=   O      A2     B      A1
       Pat frequency= 0.5840 0.0060
Maternal genotype     Likelihood of A2 phenotype:
       Ovum   M freq
A1     A2     0.0253   0.0148 0.0002
A1     O      0.4362          0.0026