In theory no enhancements were needed to DNA·VIEW to cater to SNP's; they could be treated as a 4-allele or 2-allele STR system. However, several changes make dealing with SNP systems more convenient.
SNP, to associate with SNP loci.
Automatic Kinship has a brilliant new option, Simulate, that answers questions like these. that answers questions like this. The idea got some impetus several years ago when I was given a paper to referee called "Prospective Kinship Analysis." The authors tried to analyze and predict the likely benefit of DNA typing to resolve some particular inheritance dispute. The concept was good but the execution was not. I suggested rewritting but I never saw it again. I felt constrained from trying to write on the subject myself after that, but saw no reason not to write a computer program.
The general problem that Simulate tackles is this: Given a collection of people and conflicting hypotheses as to how they may be related, how helpful is future DNA testing (or further DNA testing, as the case may be) likely to be in resolving the conflict?
The method of solution is to assign genotypes at random simulating nature's laws of genetics, compute the consequent likelihood ratio, and do this many times. The result of running the Simulate program is thus not a single number nor a yes/no answer, but a large collection of alternate possible numbers, whose range and distribution mimic the range of expectable results from DNA typing. From this output you can judge whether a decisive result is certain, likely, or unlikely.
A new feature of DNA odds useful for amusement or demonstrations - lets you generate random DNA profiles. Enter # for an allele and the program will substitute an allele randomly selected based on the frequencies of the relevant database.
|Rare allele report. locus: TPOX 2p25-p24 STR|
|All alleles (*=beep when typed in):|
Asterisks flag alleles that are not part of the allele resolution filter (ARF) if there is an ARF, i.e. those that cause a warning beep when typed in.
HOST ACCESS ERROR.
You can remove the read-only status and fix the problem by right-clicking on the file name in Windows and changing the "properties".
|16 bit MS-DOS Error
The system cannot open COM1 port requested by the application. Click 'Close' to terminate the application
dnaview\dnaview.bat, remove the
E256at the end of the line (near the end of the file) that includes
dnaview\aplii\config.apl, remove any line that begins
Printing from DNAVIEW or PATER when running under XP is tricky because they print to LPT1 (or LPT2) and Windows does not allow user access to those devices. Moreover, unlike Windows 98, Windows XP does not have a "capture printer port" option on the printer properties window.
The effect can be achieved, however, with the
NET USE command
net use LPT1 "\\ODYY\ODYY 970 USB" Persistent=yes
Persistent=yesmeans persisting after the computer is shut down and restarted.